2. Signaling Pathways
  3. Neuronal Signaling
  4. Imidazoline Receptor
  5. Imidazoline Receptor Antagonist

Imidazoline Receptor Antagonist

Imidazoline Receptor Antagonists (4):

Cat. No. Product Name Effect Purity
  • HY-14561A
    Idazoxan hydrochloride
    		Antagonist 99.32%
    Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism.
  • HY-B1416A
    Efaroxan hydrochloride
    		Antagonist 99.94%
    Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease.
  • HY-101170
    BU224 hydrochloride
    		Antagonist
    BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research.
  • HY-101374A
    AGN 192403 hydrochloride
    		Antagonist
    AGN 192403 (BRD4780) hydrochloride is an I1-Imidazoline receptor antagonist for cardiovascular and neurological research.